A warm welcome to Nidal Khatib who joined the Developmental Biomechanics group in January. Nidal will be using our mechanostimulation bioreactor system to explore mechanotransductory pathways and mechanisms acting during prenatal skeletal development. His project is a collaboration with Prof David Hoey from Trinity College Dublin, and is funded by Niamh’s ERC Starting Grant.
Aurélie‘s paper (on which Yuming and Rebecca are also authors) entitled “Short-term foetal immobility temporally and progressively affects chick spinal curvature and anatomy and rib development” has been published in eCM (European Cells and Materials). The paper describes how a very short period of paralysis during prenatal development can have severe and lasting effects on development of the spine and ribs, as summarised in the graphical abstract. This work has consequences for understanding congenital scoliosis, for which a change or reduction in fetal movements could be an important factor. The project was funded by the Leverhulme Trust and was a collaboration with Prof James Iatridis in the Icahn School of Medicine at Mount Sinai, New York, USA. View the paper for free here.