Saima’s paper published in eCM

Saima‘s paper funded by the ERC characterising the collagens in the developing skeletal rudiment was published in eCM.  We used immuno-fluorescence to look at the major and minor collagens in sections of the humerus at TS22 (e13.5, before formation of the primary ossification centre), TS25 (e15.5) and TS27 (e17.5).

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Several collagens change substantially with the progression of the ossification centre, like for example Col V.

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Some develop amazingly complex structures over the period of development studied, like Col II (green) and XI (grey).

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Congratulations Saima on this beautiful work!