The shape of our joints is critical to their function and control, but there are significant gaps in our understanding of how joint shapes develop and form. However, there is significant evidence from clinical conditions in babies that fetal movements are critical to normal morphogenesis of the joints. Developmental dysplasia of the hip (DDH), where the hip joint is unstable or even dislocated, is more common when fetal movements are restricted or reduced. Arthrogryposis, where multiple joints are abnormally shaped and oriented, is a syndrome with abnormal fetal movements as the key feature. In this project, we are investigating how mechanical forces due to fetal movement mould synovial joints to gain a better understanding of musculoskeletal conditions affecting newborns and children.

 

Publications

Ahmed, S., and Nowlan N.C., 2020. Initiation and emerging complexity of the collagen network during prenatal skeletal development. European Cells and Materials 39, pp. 136-155. (link- open access)

Sotiriou, V., Rolfe R.A., Murphy, P. and Nowlan, N.C., 2019Effects of abnormal muscle forces on prenatal joint morphogenesis in miceJournal of Orthopaedic Research 37 (11), pp. 2287-2296. (JOR link) (BioRxiv link to original submission)

Ford CA, Nowlan NC, Thomopoulos S, Killian M. “Impaired muscular loading during post-natal growth leads to altered structure of the developing murine hip”, in press (Early View). Journal of Orthopaedic Research (link)

Chandaria VV, McGinty J, Nowlan NC, “Characterising the Effects of in Vitro Mechanical Stimulation on Morphogenesis of Developing Limb Explants”, 2016. Journal of Biomechanics 49 (15), pp. 3635–3642. (link) (pdf)

Giorgi M, Carriero A, Shefelbine SJ, Nowlan NC, “Effects of normal and abnormal loading conditions on morphogenesis of the prenatal hip joint: application to hip dysplasia”, 2015. Journal of Biomechanics 48 (12), pp. 3390–3397(link) (pdf)

Giorgi M, Carriero A, Shefelbine SJ, Nowlan NC, “Mechanobiological simulations of prenatal joint morphogenesis”, 2014. Journal of Biomechanics. 47 (5), pp. 989–995. (link) (pdf)