Saima’s paper published in eCM

Saima‘s paper funded by the ERC characterising the collagens in the developing skeletal rudiment was published in eCM.  We used immuno-fluorescence to look at the major and minor collagens in sections of the humerus at TS22 (e13.5, before formation of the primary ossification centre), TS25 (e15.5) and TS27 (e17.5).

Screen Shot 2020-02-27 at 09.45.26

Several collagens change substantially with the progression of the ossification centre, like for example Col V.

Screen Shot 2020-02-27 at 09.47.05

Some develop amazingly complex structures over the period of development studied, like Col II (green) and XI (grey).

Screen Shot 2020-02-27 at 09.48.39

Screen Shot 2020-02-27 at 09.49.02

Congratulations Saima on this beautiful work!

Vivien’s first paper published in JOR

Vivien‘s first first-author paper entitled “Effects of Abnormal Muscle Forces on Prenatal Joint Morphogenesis in Mice” has been published in the Journal of Orthopaedic Research. The paper characterises the effects of absent or reduced muscle on prenatal development of the major synovial joints. Vivien used image registration to qualitatively and quantitatively compare joint shapes between muscleless, reduced-muscle and normal mice. Different joints were affected more than others, and what we found most interesting is that a reduction in muscle often led to *more* severe effects than no muscle- like in the humeral distal condyles (blue: control, yellow: reduced-muscle, purple: muscleless)

Congratulations Vivien! You can access the final version of the paper here, or the submitted version here if you don’t have access to JOR.

Aurélie’s latest findings on timing of movement for spine development published

Aurélie‘s paper (on which Yuming and Rebecca are also authors) entitled “Short-term foetal immobility temporally and progressively affects chick spinal curvature and anatomy and rib development” has been published in eCM (European Cells and Materials). The paper describes how a very short period of paralysis during prenatal development can have severe and lasting effects on development of the spine and ribs, as summarised in the graphical abstract. This work has consequences for understanding congenital scoliosis, for which a change or reduction in fetal movements could be an important factor. The project was funded by the Leverhulme Trust and was a collaboration with Prof James Iatridis in the Icahn School of Medicine at Mount Sinai, New York, USA. View the paper for free here.

Perren Award paper on link between hip dysplasia and fetal movements published

Stefaan’s final and Perren Award winning paper from his postdoc in the Developmental Biomechanics has been published online in the Journal of Biomechanics. In the paper, the effects of different risk factors for hip dysplasia (such as fetal breech position, first born babies and oligohydramnios (reduced amniotic fluid)) on fetal kicks and the stresses and strains in their hip joints are quantified. Kick force, stress and strain were found to be significantly lower in cases of breech position and oligohydramnios. Similarly, firstborn fetuses were found to generate significantly lower kick forces than non-firstborns.

ESB S.M. Perren Award for paper on fetal movement-hip dysplasia link

Congratulations to Stefaan and co-authors whose paper entitled “Altered Biomechanical Stimulation of the Developing Hip Joint in Presence of Hip Dysplasia Risk Factors” (soon to be published in the Journal of Biomechanics) has been awarded the 2018 S.M. Perren Award by the European Society of Biomechanics! Stefaan will present a plenary lecture of the World Congress of Biomechanics in Dublin, Ireland in July. hip_dysplasia.png

Fetal movement sensor paper published

Our paper on developing a new type of sensor for fetal movements has been published in PLoS One! The paper describes how acoustic sensors are combined with accelerometers for the first time. The sensor was able to detect and identify the short, rigorous ‘startle’ movements of the fetus. Further development is ongoing, but this is an important first step! The work builds on a patent held by the several of the authors, including Niamh.

Citation: Lai J, Woodward R, Alexandrov Y, ain Munnee Q, Lees CC, Vaidyanathan R, Nowlan NC. Performance of a wearable acoustic system for fetal movement discrimination. PloS one. 2018 May 7;13(5):e0195728.

journal.pone.0195728.g001 (1).PNG

Paper on fetal movement forces published in Interface

Stefaan‘s work on quantifying the stresses and strains induced by fetal kicks over gestation has been published in the Journal of the Royal Society Interface. The work attracted a lot of publicity, being featured by Nature, Science and Newsweek and on the Imperial College website. Congratulations Stefaan! See here for the online version of the paper, and access the pdf here.

Spine development abnormal when fetus is immobile

Rebecca’s paper entitled “Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape” has been accepted by the Journal of Orthopaedic Research! Former UROP and MRes students (James, Tyler and Zuheir) are also co-authors, as are Nowlan group collaborators Michelle Oyen (University of Cambridge, UK) and James Iatridis (Icahn School of Medicine at Mount Sinai, NY, USA).